Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin

The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by triethylene glycol chain were synthesized characterized. these complexes, the phthalocyanine was used as potential photosensitizer for PDT tin complex selected cytostatic moiety. dyads composed complexes exhibited high cytotoxicity, in absence light stimulation, against MCF-7 human breast cells with low LC50 values range 0.016–0.453 µM. addition, showed superior cytotoxicity than their mixture equimolar component, accompanied higher activity towards compared healthy fibroblasts. However, under irradiation zinc unit (at 650 nm) no could be detected, due most likely quenching singlet excited state nearby according photoinduced electron transfer process. This demonstrates heterometallic anticancer chemotherapeutics complex, it highlights that development such requires sensitizer preserves its photophysical properties particular oxygen sensitization ability conjugate order combine drug.